Tumorigenesis and Neoplastic Progression ADAM 12 Is Selectively Overexpressed in Human Glioblastomas and Is Associated with Glioblastoma Cell Proliferation and Shedding of Heparin-Binding Epidermal Growth Factor

Takahide Kodama,* Eiji Ikeda,* Aiko Okada,* Takashi Ohtsuka,* Masayuki Shimoda,* Takayuki Shiomi,* Kazunari Yoshida, Mitsutoshi Nakada, Eiko Ohuchi, and Yasunori Okada* From the Departments of Pathology * and Neurosurgery, School of Medicine, Keio University, Tokyo; the Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, Kanazawa; and Daiichi Fine Chemical Company, Limited, Takaoka, Japan