Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-aryliso- quinolin-1-ones as potent and selective inhibitors

Helen A. Paine,Amit Nathubhai,Esther C. Y. Woon,Peter T. Sunderland,J. Pauline, Wood,Mary F. Mahon,Matthew D. Lloyd,Andrew S. Thompson,Teemu Haikarainen,Mohit Narwal,Michael D. Threadgill

semanticscholar（2015）

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摘要

Paine, HA, Nathubhai, A, Woon, ECY, Sunderland, PT, Wood, PJ, Mahon, MF, Lloyd, MD, Thompson, AS, Haikarainen, T, Narwal, M, Lehtio, L & Threadgill, MD 2015, 'Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro', Bioorganic and Medicinal Chemistry, vol. 23, no. 17, pp. 5891-5908. https://doi.org/10.1016/j.bmc.2015.06.061

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