Thalidomide , and Pomalidomide Reactivate the Epstein-Barr Virus Lytic Cycle Through Phosphoinositide 3-kinase Signaling and Ikaros Expression Running title : Immunomodulatory drugs reactivate lytic EBV

Departments of Lymphoma and Myeloma, Biostatistics, and Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand; Urology Department, ShengJing Hospital, China Medical University, ShenYang, China; McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI; and Birmingham Cancer Research UK Cancer Centre, School of Cancer Sciences, University of Birmingham, Birmingham, UK.