Hippocampal activation , memory performance in young and old , and the risk for sporadic Alzheimer ’ s disease converge genetically to calcium signaling

Importance—Human episodic memory performance is linked to the function of specific brain regions, including the hippocampus, declines as a result of increasing age, and is markedly disturbed in Alzheimer’s disease (AD), an age-associated neurodegenerative disorder affecting Correspondence to: andreas.papas@unibas.ch, angela.heck@unibas.ch. +Co-senior author Author contributions: A.H., M.F., H.B., F.J., H.K., W.M., S.R-H, M.W., S.We., D. J.-F. d. Q. & A.P. designed and conceptualized the study. A.H., M.F., B.A., D.C., L.G., V.F., F.J., H.K., A.M., M.P., S.R-H, C.V., M.W., S. We., S. Wo. & A.P. did the data analysis. F.H., H.B., W.M., M.P., K.S., M.W., S.We. & S.Wo. were responsible for data collection and preparation. D. J.-F. d. Q. & A.P. supervised the project. All authors contributed to the writing of the manuscript. Conflicts of interest: There are no conflicts of interest to declare. HHS Public Access Author manuscript JAMA Psychiatry. Author manuscript; available in PMC 2017 February 03. Published in final edited form as: JAMA Psychiatry. 2015 October ; 72(10): 1029–1036. doi:10.1001/jamapsychiatry.2015.1309. A uhor M anscript