Developing Three-Dimensional Human Brain Tumor Models For Personalized Drug Screening

density of extruded liquid was found higher than theoretical density of the buffer solution by our calculation, which suggested a physicochemical change inside the cross-linked matrix as well as possible leaking of uncross-linked polymer, which supported our hypothesis regarding HRP and cross-linking density. Additionally, the ultrastructure of Gtn-HPA with goat marrow stem cells embedded was directly observed, for the first time, by high resolution electron microscopy without coatings or environmental controls. Extracellular matrix surrounding seeded cells was found remodeled and densified on Day 7.