Substrate spectrum extension of PenA in Burkholderia thailandensis with a 2 single amino acid deletion Glu 168 del 3 4

1 Substrate spectrum extension of PenA in Burkholderia thailandensis with a 2 single amino acid deletion Glu168del 3 4 Hyojeong Yi1§, Karan Kim1§, Kwang-Hwi Cho, Oksung Jung, and Heenam Stanley Kim* 5 6 Department of Medicine, College of Medicine, Korea University, Anam-Dong, Seongbuk-Gu, 7 Seoul 136-705, Korea; School of Systems Biomedical Science and Research Center for 8 Integrative Basic Science, Soongsil University, Seoul 156-743, Korea 9 10 11 Running Title: Glu168del in a β-lactamase PenA 12 13 14