Platelet Rich Plasma : A Potential Treatment Option in Hyper Pigmentation of Skin

Melasma is characterized by symmetrical hyper pigmented macules and patches on the sun exposed area of the face, commonly on forehead, cheeks, lips and nose especially in women. It is an acquired pigmentary disorder. Its pathogenesis is not yet fully understood but the common risk factors for melasma include pregnancy, oral contraceptives, genetic factor, Ultraviolet exposure. Most recently data supported that pathogenesis of melasma involves vascular growth factors, Wnt pathway modulator genes and inducible Nitric Oxide Synthase (iNOS) expression and down regulation of H19 genes with a still unresolved pathogenesis. A wide variety of treatments include hydroquinone, tretinoin, kojic acid, and tranexamic acid, azelaic acid, glycolic acid, laser, broad spectrum sunscreen and sun avoidance. Though it is effective treatment, adverse effects have also been identified. In recent times, Platelet Rich Plasma (PRP) is fetching attention in aesthetic medicine. Interestedly, this study aimed to assess the effectiveness of PRP injection intradermally. It demonstrated that PRP injection resulted in the reduced hyper pigmented lesions in melasma with fewer side effects. Hence, PRP could be a promising treatment and hope for new safe and effective treatment options. Raghvendra Bohara1, Nilesh Bhamre1, Jeevitaa Kshersagar1, Kishor Tardalkar1, Shashikant Desai2, Mayuresh Despande3 and M G Joshi1* 1Department of Stem Cells and Regenerative Medicine, D.Y. Patil University, Kolhapur, India 2Stem Plus Cryopreservation, Maharashtra, India 3Department of Surgery, D.Y. Patil University, Kolhapur, India