Poster Presentation MS036.P07 Antitumor/antiviral drugs target on STING

STING (Stimulator of Interferon Genes, also known as ERIS, MITA and MPYS) is an important adaptor protein in innate immunity. It plays a key role in cytosolic DNA mediated IFN production. STING is the direct sensor of cyclic dinucleotides(CDN) in cytosol, including c-di-GMP from pathogen and cGAMP synthesized by cGAS after DNA stimulating. After binding to and activated by CDNs, STING recruits and activates TBK1 and IRF3 by its C terminal tail. IRF3 is phosphorylated and then dimerize to enter nucleus, resulting in type I interferon (IFN) production.