Cytoplasmic destruction of p 53 by the endoplasmic reticulum-resident ubiquitin ligase ‘

Satoshi Yamasaki, Naoko Yagishita, Takeshi Sasaki, Minako Nakazawa, Yukihiro Kato, Tadayuki Yamadera, Eunkyung Bae, Sayumi Toriyama, Rie Ikeda, Lei Zhang, Kazuko Fujitani, Eunkyung Yoo, Kaneyuki Tsuchimochi, Tomohiko Ohta, Natsumi Araya, Hidetoshi Fujita, Satoko Aratani, Katsumi Eguchi, Setsuro Komiya, Ikuro Maruyama, Nobuyo Higashi, Mitsuru Sato, Haruki Senoo, Takahiro Ochi, Shigeyuki Yokoyama, Tetsuya Amano, Jaeseob Kim, Steffen Gay, Akiyoshi Fukamizu, Kusuki Nishioka, Keiji Tanaka and Toshihiro Nakajima* Department of Genome Science, Institute of Medical Science, St Marianna University School of Medicine, Kawasaki, Japan, GenExl, Inc. Biomedical Research Center, Taejon, South Korea, Division of Breast and Endocrine Surgery, Institute of Medical Science, St Marianna University School of Medicine, Kawasaki, Japan, The First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan, Department of Orthopedic Surgery, Kagoshima University, Faculty of Medicine, Kagoshima, Japan, Department of Dermatology and Laboratory of Molecular Medicine, Kagoshima University, Faculty of Medicine, Kagoshima, Japan, Department of Anatomy, Akita University School of Medicine, Akita, Japan, National Hospital Organization Sagamihara National Hospital, Kanagawa, Japan, Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo, Japan; Protein Research Group, RIKEN Genomic Sciences Center, Yokohama, Japan, Department of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Aspect of Functional Genomic Biology, Center of Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Japan, Rheumatology, Immunology and Genetics Program, Institute of Medical Science, St Marianna University School of Medicine, Kawasaki, Japan and Laboratory of Frontier Science, The Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan