Identification of a novel crizotinib-sensitive NR-110219 & MIR 4432-ALK gene fusion in a patient with lung adenocarcinoma by high-throughput sequencing of circulating tumor DNA and tumor-derived DNA from pleural effusion fluid

Mengdie Qi,Yanfei Yang,Yangyang Gu,Hequan Li

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE（2018）

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摘要

We found a novel NR-110219 & MIR4432-ALK gene fusion in a lung adenocarcinoma patient by highthroughput sequencing of circulating tumor DNA and tumor-derived DNA from pleural effusion fluid and the patient responded well to crizotinib.

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关键词

Lung adenocarcinoma, NR-110219 & MIR4432-ALK gene fusion, ctDNA, crizotinib

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