A Salmonella Toxin Promo tes Persister Formation through Acetylation of tRNA Graphical

In Brief Persisters are non-growing, antibioticinsensitive bacteria involved in recalcitrance of infections. Salmonella forms intra-macrophage persisters through the action of toxin-antitoxin modules. Cheverton et al. reveal that TacT is an acetyltransferase toxin blocking the primary amine of amino acids on charged tRNAs. They identify a detoxifying mechanism counteracting TacT-dependent growth arrest, allowing growth resumption.