Inflammation in metabolically healthy and metabolically abnormal adolescents : 1 the HELENA study . 2 3

1 the HELENA study. 2 3 Esther María Gonzalez-Gil, PhD1,2,3,4, Cristina Cadenas-Sanchez Msc5, Javier 4 Santabárbara PhD6, Gloria Bueno-LozanoPhD7, Iris Iglesia Msc1,2,3,8, Marcela 5 González-Gross PhD4,9, Denes Molnar PhD10, Frederic Gottrand PhD11, Stefaan De 6 Henauw PhD12, Antonios Kafatos PhD13, Kurt Widhalm PhD14, Yannis Manios PhD15, 7 Alfonso Siani PhD16, Francisco Amaro-Gahete PhD17, Azahara I. Rupérez PhD1, David 8 Cañada PhD9 , Laura Censi Msc18, Mathilde Kersting PhD19, Jean Dallongeville PhD20, 9 Ascensión Marcos PhD21,4, Francisco B. Ortega PhD 5,22 and Luis A. Moreno PhD 1,2,3,4 10 on behalf of the HELENA study group*. 11 12 1GENUD "Growth, Exercise, NUtrition and Development" Research Group, Faculty of 13 Health Sciences. Universidad de Zaragoza, Spain. 14 2Instituto Agroalimentario de Aragón (IA2). 15 3Instituto de Investigación Sanitaria Aragón (IIS Aragón). 16 4Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y 17 Nutrición (CIBERObn). 18 5PROFITH “PROmoting FITness and Health through physical activity” research group. 19 Department of Physical Education and Sport, Faculty of Sport Sciences, University of 20 Granada, Spain 21 6Department of Preventive Medicine and Public Health, University of Zaragoza. 22 Zaragoza, Spain. 23 7Service of Pediatrics, Hospital Clínico Universitario "Lozano Blesa", Zaragoza, Spain. 24 8Red de Salud materno-infantil y del desarrollo (SAMID). 25