Synthesis and Biological Characterization of New 2 Aminophosphonates for Mitochondrial pH Determination by 31 P 3 NMR Spectroscopy

2 Aminophosphonates for Mitochondrial pH Determination by P 3 NMR Spectroscopy 4 Marcel Culcasi,† Gilles Casano,† Ceĺine Lucchesi,† Anne Mercier,† Jean-Louis Cleḿent,† Valeŕie Pique,† 5 Laure Michelet,‡ Anja Krieger-Liszkay,‡ Maxime Robin,† and Sylvia Pietri*,† 6 †Aix-Marseille Universite,́ CNRS UMR 7273, Equipe Sondes Molećulaires en Biologie et Stress Oxydant, Institut de Chimie 7 Radicalaire, Marseille, France 8 ‡CNRS UMR 8221, Institut de Biologie et de Technologie de Saclay (iBiTec-S), CEA Saclay, Gif-sur-Yvette, France