Natural variation OsCd 1 V 449 contributes to reducing cadmium accumulation in rice grain 1

1Key Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, 5 P. R. China 6 2Key Lab of Crop Heterosis and Utilization, Beijing Key Lab of Crop Genetic Improvement, Ministry 7 of Education, China Agricultural University 8 3College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, China 9 4Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical 10 Agriculture, Chinese Academy of Sciences, Changsha, 410125, China. 11 12 #These authors contributed equally to this work 13 *Address correspondence to hezhenyan@ibcas.ac.cn, zhangl@cau.edu.cn 14 15 Abstract 16