MicroRNA-92 a Negatively Regulates TLR-triggered inflammatory response in Macrophages by Targeting MKK 4 *

Background: microRNAs (miRNAs) participate in innate immune responses. Results: MiR-92a decreases rapidly in macrophages once stimulated with TLR ligands, and miR-92a controls inflammatory response by targeting MKK4/JNK/C-JUN pathway. Conclusion: TLR-mediated miR-92a reduction feedback enhances TLR-triggered inflammatory response. Significance: Our findings reveal a novel positive feedback loop in which TLR-reduced miR-92a expression functions to regulate the innate inflammatory responses.