Gastric adenocarcinoma with hepatoid adenocarcinoma : A case report and literature review

Hepatoid adenocarcinoma of the stomach (HAS) is a subtype of gastric tumors with hepatoid features that frequently produces serum alpha fetoprotein (AFP) [1]. Although the pathogenesis and molecular biology of HAS is thought to be due to cellular trans-differentiation from glandular to hepatoid type, the underlying mechanism remains unknown. As its clinical diagnosis is rare and the tumor is difficult to diagnose with gastroscopic biopsy, this disease is often misdiagnosed. Herein, we present a case from our hospital (Dalian Municipal Central Hospital, Dalian, China) to help improve our understanding of HAS and provide evidence for its treatment and prognosis.