Pdcl(C3H5)(Dppb)-Catalysed Direct Arylation of Bromobenzylacetamide Derivatives

At the dawn of the XXI centry, organic chemists have discovered that the structural unit of the molecule biaryl obtained from the arylation reaction was found in a number of reasons pharmaceutical and biologically active naturel [1]. Their use in various fields involving the development of new synthetic methodologies quickly and efficiently. One solution to this challenge lies in the formation of aryl-aryl bond involving the coupling of aryl halide with another substrate more reactive catalysed by transition metals, including palladium complexes that are today most used studied [2-6]. For our part, we are interested in the arylation reaction of bromobenzylacetamides derivatives by heteroaromatics at various substrates as patterned: furans, thiophenes, pyrroles, thiazoles catalysed by PdCl(C3H5)(dppb) solution in DMAC. The reaction mixtures is placed in a basic medium of KOAc and then refuxed [7]. Benzylacetamide heteroaryl derivatives are generally obtained in good yields and excellent regioselectivity.