An allele of CRP promoter region -717-a susceptible gene for peritoneal dialysis related peritonitis

Peritoneal dialysis-related peritonitis is one of the most common complications and the leading cause of failure in peritoneal dialysis. In addition, peritonitis significantly increases hospitalization rates and mortality. To study the relationship between peritoneal dialysis related peritonitis and high-sensitivity C-reactive protein (hs-CRP) and its promoter region -717A > G gene polymorphism, A total of 68 peritoneal dialysis related peritonitis patients and 70 peritoneal dialysis patients without peritonitis and 60 healthy individuals in the control group were enrolled. Serum levels of hs-CRP were measured by turbidimetric immunoassay. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) was used to determine the frequency of CRP promoter -717A > G genotype and its allele frequencies. Compared with non-peritonitis patients, the levels of hs-CRP and serum phosphorus were higher in patients with peritonitis, and hemoglobin and serum albumin were lower (P < 0.05). Logistic multivariate regression analysis showed that baseline high hs-CRP levels were risk factors for peritoneal dialysis related peritonitis (OR = 2.228). There were no significant differences in the frequency distribution of AA, AG and GG and allele A and G in genotype -717A > G between the peritoneal dialysis group and the control group (X2 = 1.976 and 1.893, P > 0.05). There was no significant difference in the frequency distribution of AA, AG and GG in -717A > G genotype in patients with peritonitis and non-peritonitis (X2 = 4.076, P > 0.05), and the frequency distribution of allele A in peritonitis group was higher than that in non-peritonitis group (X2 = 4.639, P = 0. 031), suggesting that microinflammatory state is common in peritoneal dialysis patients. Elevated hs-CRP may be an independent risk factor for peritoneal dialysis-related peritonitis. The A allele of the CRP promoter region -717 may be a susceptible gene for peritonitis in peritoneal dialysis patients.