GLYX-13 Ameliorates Schizophrenia-Like Phenotype Induced by MK-801 in Mice : Role of Hippocampal NR 2 B and DISC 1

It is with great interest we have read the article "GLYX-13 Ameliorates Schizophrenia-Like Phenotype Induced by MK-801 in Mice: Role of Hippocampal NR2B and DISC1" (Zhou et al., 2018). Interestingly, this study showed that GLYX-13 prevents hippocampal N-methyl-D-aspartate receptor subtype 2B-Disrupted in schizophrenia 1 (GluN2B-DISC1) signaling and behavioural changes induced by schizophrenia-mimetic drug MK801 in mice. To confirm GluN2B directly regulating DISC1, these researchers showed that the effects of GLYX-13 were vanished after GluN2B knockdown in mice. Publication Details Xie, Y. & Huang, X. (2018). Commentary: GLYX-13 Ameliorates Schizophrenia-Like Phenotype Induced by MK-801 in Mice: Role of Hippocampal NR2B and DISC1. Frontiers in Molecular Neuroscience, 11 315-1-315-3. This journal article is available at Research Online: https://ro.uow.edu.au/ihmri/1326 GENERAL COMMENTARY published: 05 September 2018 doi: 10.3389/fnmol.2018.00315 Frontiers in Molecular Neuroscience | www.frontiersin.org 1 September 2018 | Volume 11 | Article 315 Edited by: