Human knockouts and phenotypic analysis 1 in a cohort with a high rate of consanguinity 2 3

Danish Saleheen†*, Pradeep Natarajan†, Irina Armean, Wei Zhao, Asif Rasheed, 4 Sumeet Khetarpal, Hong-Hee Won, Konrad J. Karczewski, Anne H. O’Donnell5 Luria, Kaitlin E. Samocha, Namrata Gupta, Mozzam Zaidi, Maria Samuel, Atif 6 Imran, Shahid Abbas, Faisal Majeed, Madiha Ishaq, Saba Akhtar, Kevin Trindade, 7 Megan Mucksavage, Nadeem Qamar, Khan Shah Zaman, Zia Yaqoob, Tahir 8 Saghir, Syed Nadeem Hasan Rizvi, Anis Memon, Nadeem Hayyat Mallick, 9 Mohammad Ishaq, Syed Zahed Rasheed, Fazal-ur-Rehman Memon, Khalid 10 Mahmood, Naveeduddin Ahmed, Ron Do, Ronald M. Krauss, Daniel G. 11 MacArthur, Stacey Gabriel, Eric S. Lander, Mark J. Daly, Philippe Frossard†, John 12 Danesh†, Daniel J. Rader†, Sekar Kathiresan†* 13 14