One Pot Synthesis of Certain Novel Substituted Analogous of 1 , 4-Dihydropyridines and their Antimicrobial Activities

A novel class of 4-aryl-2, 6-dimethyl-3,5-dicarbomethoxy/ethoxy-4-(Substituted phenyl)-1, 4dihydropyridine has been synthesized by solvent free, simple, efficient method, without using any catalyst, modified Hantzsch condensation reaction making use of substituted benzaldehyde and β-ketoester with ammonium acetate under stirring and operative at room temperature.The newly synthesized compounds were characterized by their spectral analysis and evaluated for in vitro antibacterial activity against different Gram +ve and Gram -ve bacteria and antifungal activity against Fungi. The preliminary screening results revealed that some of the compounds possess promising antimicrobial activity. The target compounds 4b, 4d and 4e showed good inhibition on pathogen Escherichia Coli, Staphylococcus Aureus and Aspergilluse Niger and moderate activity against Candida Albicans.