1 Cross-talk between PRMT 1-mediated methylation and ubiquitylation on RBM 15 controls RNA splicing 1

7 1. Department of Biochemistry and Molecular Genetics, UAB Stem Cell Institute, The University of 8 Alabama at Birmingham, Birmingham, AL 35294, USA. 9 2. Program of Molecular Pharmacology, Sloan Kettering Institute, New York, NY 10021, USA. 10 3. HOPP, Sloan Kettering Institute, New York, NY 10021, USA. 11 4. School of Life Sciences, Tsinghua University, Beijing, 100084 China. 12 5. Department of Pharmaceutical & Biomedical Sciences, The University of Georgia, Athens, GA 13 30602, USA 14 6. Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, 15 ON K1H 8M5, Canada. 16 7. Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University & Henan 17 Cancer Hospital, Zhengzhou 450008, China 18 8. Department of Neurology, Comprehensive Cancer Center, The University of Alabama at 19 Birmingham, Birmingham, AL 35294, USA. 20 9. Division of Hematology and Oncology, University of Massachusetts Medical School, 364 21 Plantation St, Worcester, MA 01605, USA. 22 10. Cell Signaling Inc. 3 Trask lane, Danvers, MA 01923, USA. 23 11. Computational Biology Program, Sloan Kettering Institute, New York, NY 10021, USA. 24 12. Division of Preventive Medicine, The University of Alabama at Birmingham, Birmingham, AL 25 35294, USA. 26 27 * These authors contribute equally. 28