Vasomotor Function of orcine Coronary Arteries Distal to irolimus-Eluting Stents

esults The SES showed increased lumen area and reduced neointima; abnormal vasomotor funcion of conduit arteries distal to SES also was observed. Contraction to endothelin-1 was significantly nhanced for SES compared with both BMS and POLY. Endothelium-dependent relaxation to a maxial dose of substance P was attenuated for SES compared with both BMS and POLY (46 6% vs. 1 3% and 78 3%, respectively, p 0.001). Endothelium-independent relaxation to sodium itroprusside was potentiated for SES, compared with BMS and POLY (100 5% vs. 69 7% and 7 5%, respectively, p 0.02).