TREIMM 1355 No . of Pages 13 Review NLRP 6 : A Multifaceted Innate Immune Sensor

NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR) innate immune receptor family, regulates inflammation and host defense against microorganisms. Similar to other NLRs, NLRP6 not only participates in inflammasome formation, but is also involved in nuclear factor-kB (NFkB) andmitogen-activated protein kinase (MAPK) signaling regulation and facilitationof gastrointestinal antiviral effector functions.Additionally,NLRP6contributes to the regulation of mucus secretion and antimicrobial peptide production, thereby impacting intestinal microbial colonization and associatedmicrobiomerelated infectious, autoinflammatory, metabolic, and neoplastic diseases. However, several of the mechanisms attributed to the functions of NLRP6 remain debatable, leaving open questions as to the relevantmolecularmechanisms and interacting partners, and putative human relevance. We herein discuss recent findings related to NLRP6 activity, while highlighting outstanding questions and future perspectives in elucidating its roles in health and disease.