G 9 a regulates temporal preimplantation developmental program 1 and lineage segregation in blastocyst 2 3

3 Jan J Zylicz* 2, , Maud Borensztein* , Frederick CK Wong , Yun Huang , Caroline 4 Lee , Sabine Dietmann, M. Azim Surani 2 5 6 * contributed equally 7 # corresponding author 8 1 Wellcome Trust/Cancer Research United Kingdom Gurdon Institute, University of 9 Cambridge, Cambridge, United Kingdom 10 2 Department of Physiology, Development and Neuroscience, University of Cambridge, 11 Cambridge, United Kingdom 12 3 Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, 13 Cambridge, United Kingdom 14 15 16 ABSTRACT 17