Genome-Wide Association Study Implicates HLA-C * 01 : 02 as a Risk Factor at the Major Histocompatibility Complex Locus in Schizophrenia Irish Schizophrenia Genomics

Jenefer M Blackwell,Elvira Bramon,Aiden Corvin,Panos Deloukas, Janusz, Jankowski, Hugh, Markus, Christopher, G athew,Colin NA Palmer,Robert Plomin,Anna Rautanen,Richard C Trembath,Ananth C Viswanathan,Eleni Giannoulatou,Richard Pearson,Amy Strange,Avazeh Tashakkori-Ghanbaria,Damjan Vukcevic, Sarah E Hunt,Sarah Edkins,Rhian Gwilliam,Suzannah J Bumpstead,Serge Dronov,Matthew Gillman, mma Gray,Naomi Hammond, Alagurevathi Jayakumar, Jennifer Liddle,Simon C Potter,Radhi Ravindrarajah, Matthew Waller,Paul Weston,Sara Widaa,Pamela Whittaker,Ines Barroso,Paul Cormican,Elaine M Kenny,Brandon Wormley,Gary Donohoe,Emma Quinn, Roisin Judge, Liz, Cummings, Eric, Kelleher, Patrick McKeon,Colm McDonald,John L Waddington

semanticscholar（2012）

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摘要

Results: One hundred eight SNPs were taken forward for replication in an independent sample of 13,195 cases and 31,021 control subjects. The most significant associations in discovery, corrected for genomic inflation, were (rs204999, p combined 1.34 10 9 and in combined amples (rs2523722 p combined 2.88 10 ) mapped to the major histocompatibility complex (MHC) region. We imputed classical human leukocyte antigen (HLA) alleles at the locus; the most significant finding was with HLA-C*01:02. This association was distinct from the top SNP signal. The HLA alleles DRB1*03:01 and B*08:01 were protective, replicating a previous study.

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