Benefic Effect of Apple Vinegar Cider on Lipid Profile in Streptozotocin-Diabetic Rats

The benefic effects of vinegar have been known for more than a century and have been demonstrated in animal as well as human studies. The purpose of the present study was to investigate the effects of apple cider vinegar on lipid profile, biomarkers of atherosclerosis and cardiovascular diseases. Male albino rats were used for the present investigation. The animals were fasted overnight and diabetes mellitus (DM) was induced by a single intraperitoneal injection of freshly prepared streptozotocin (STZ) (65mg/kg) in citrate buffer. Vinegar cider was orally administrated to the diabetic rats. Control rats were injected with citrate buffer only and the animals were considered as diabetic, if their blood glucose values were above 250mg/dl on the third day after STZ injection. The treatment had started on the fourth day after STZ injection and this day was considered as the first day of treatment that was continued for 4 weeks. In the plasma of the animals we determined the total cholesterol (CT), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C) and triglyceride (TG) levels, alanine amino transferase (ALT) and aspartate amino transferase (AST) activities. We evaluated also CT/HDL-C, TG/HDL-C and LDL/HDL-C ratios and the atherogenic index (AI). Our treatment significantly reduced the CT values, LDL-C levels, TG levels, CT/HDL-C ratio, TG/HDL-C ratio, LDL/HDL-C ratio, AI, ALT and AST activities but increased HDL-C levels. These results indicate that apple cider improved the serum lipid profile related to the cardiovascular risk in diabetes mellitus. [Ben Hmad H, Khlifi S, Ben Jemaa H, Gara S, Benzarti A, Aouidet A. Benefic Effect of Apple Vinegar Cider on Lipid Profile in Streptozotocin-Diabetic Rats. Life Sci J 2017;14(7):40-44]. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online). http://www.lifesciencesite.com. 7. doi:10.7537/marslsj140717.07.