Quantitative Accuracy of Temporally Constrained Reconstruction in Dynamic Contrast Enhanced MRI

Introduction: Dynamic contrast-enhanced (DCE)-MRI is a powerful tool for evaluating tumor vascular response and assessment of antiangiogenic and antivascular therapeutics. High temporal resolution is needed to accurately determine tumor enhancement kinetics. One of the strategies to enhance temporal resolution is the undersampling of k-space data, including radially acquired schemes. Temporally constrained reconstruction (TCR) [1] has also recently been developed for dynamic MR imaging to achieve high image quality at high undersampling factors. However, whether this technique can achieve accurate quantitative MRI measurements has not been investigated. In this work, an enhanced simulation experiment was conducted to evaluate of the accuracy of TCR for the assessment of DCE-MRI perfusion parameters.