Intrinsic differences in gene expression and response to 5 cold exposure in mice

1 2 Running head: Cold-induced transcriptional changes in adipose tissues 3 4 Brown and White Adipose Tissues. Intrinsic differences in gene expression and response to 5 cold exposure in mice. 6 Meritxell Rosell, Myrsini Kaforou, Andrea Frontini, Anthony Okolo, Yi-Wah Chan, Evanthia 7 Nikolopoulou, Steven Millership, Matthew E Fenech, David MacIntyre, Jeremy O Turner, 8 Jonathan D Moore, Edith Blackburn, William J Gullick, Saverio Cinti, Giovanni Montana, 9 Malcolm G Parker, Mark Christian 10 1 Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College London, 11 Du Cane Road, London W12 ONN, UK 12 2 Section of Paediatrics, Division of Infectious Diseases, Department of Medicine, Imperial College London, Norfolk 13 Place, W2 1PG, London, UK 14 3 Department of Experimental and Clinical Medicine, Obesity Center, United Hospitals-University of Ancona 15 (Politecnica delle Marche), Ancona 60020, Italy 16 4 Warwick Systems Biology Centre, University of Warwick, Coventry, CV4 7AL, UK 17 5 Metabolic Signalling Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 18 ONN, UK 19 6 Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK 20 7 School of Biosciences at the University of Kent, Canterbury, Kent, CT2 7NJ, UK 21 8 Department of Mathematics, Statistics section, Imperial College London, 180 Queen's Gate, London SW7 2AZ, UK 22 9 Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, 23 UK. 24 25 Corresponding author: 26 Dr Mark Christian, Division of Metabolic and Vascular Health, Warwick Medical School, University 27 of Warwick, Coventry, CV4 7AL, UK. 28 Phone: 44 2476 968585 29 Email: m.christian@warwick.ac.uk 30