A new aminomethylphenol , JPC-2997 , with 1 high in vitro and in vivo antimalarial 2 activity against blood stages of 3 Plasmodium 4 5

5 Geoffrey W. Birrell, Marina Chavchich, Arba L. Ager, Hong-Ming 6 Shieh, Gavin D. Heffernan, Wenyi Zhao, Peter E. Krasucki, Kurt W. 7 Saionz2, Jacek Terpinski2, Guy A. Schiehser2, Laura R. Jacobus2, G. 8 Dennis Shanks1, David P. Jacobus2 and Michael D. Edstein1* 9 10 Department of Drug Evaluation, Australian Army Malaria Institute, Enoggera, 11 Brisbane, Queensland 4051, Australia 12 Jacobus Pharmaceutical Company, Princeton, New Jersey, USA 13 University of Miami, Miami, Florida, USA 14 15 *Corresponding author: 16 Dr Mike Edstein; Telephone: +61-7-33324930; Fax: +61-7-33324800 and E17 mail: Mike.Edstein@defence.gov.au 18 # These authors contributed equally to this study 19 20 Short Running Title: A new aminomethylphenol effective against Plasmodium 21 22