Antinociceptive activity of methanolic extract of leaves of anogessius acuminata

Antinociceptive activity of methanolic extract of leaves Anogessius acuminate was studied by peripheral/ non _narcotic model of nociception like acetic acid induced writing syndrome test and central/ narcotic models like tail flick tests. The methanolic extract of the plant, administrated orally ( 300 mg/kg, body weight) and the standard drug (piroxicam: 10mg/kg body weight, P.O) produced significant analgesic activity in acetic acid induced writhing syndromes as compared to the vehicle treated control group. In the tail flick test, the plant extract produced increase in reaction time which was significantly higher in the test and standard group compared to the control group. The plant possesses significant antinociceptive property as evidenced in all the animal models of nociception. It might possibly exert its effect through diverse mechanism that may involve both central and peripheral pathways. The preliminary phyto chemical investigation revealed the presence of steroids, alkaloids and triterpene in the methanolic extract of leaves of Anogessius acuminate which may be responsible for its antinociceptive activity.