History , Development and Genetics of the Mouse as a Laboratory Model

CHAPTER 1 Origin of the Laboratory Mouse and Related Subspecies . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 CHAPTER 2 Historical Foundations . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 CHAPTER 3 Strains, Stocks, and Mutant Mice . . . . . . . . . . . . . . . . . . . 25 CHAPTER 4 Mouse Genomics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 CHAPTER 5 Generation of Mouse Mutants by Sequence Information Driven and Random Mutagenesis . . . . . . 85 CHAPTER 6 The Mouse as an Animal Model for Human Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97 CHAPTER 7 The Mouse in Preclinical Safety Studies . . . . . . . . . . . . 111 P A R T