Complications And Their Causative Factors In Patients Undergoing Penetrating Keratoplasty

IntroductionPenetrating keratoplasty can visually rehabilitate many of those who suffer from blindness or visual impairment due to corneal diseases. The aim of the study was to know the complications and their causative factors in patients undergoing penetrating keratoplasty. Materials and methods-Thirty patients were selected for corneal replacement from Department of Ophthalmology, Guru Gobind Singh Medical College & Hospital, Faridkot for penetrating keratoplasty. Procurement of Cornea for graft placement was carried out from the Eye Bank, which were enucleated within 6 hours of death of deceased and preserved under suitable desired conditions. Data obtained was analyzed using SPSS Version-16 data analysis software. Unpaired t test was used to statistically assess the data of preoperative observations and postopetrative complications. ResultsEarly clouding of graft was noted in 1 (3.33%) case on 1st post-operative day in a male patient who had preoperative vascularisation and anterior synechiae. Seven cases (23.33%) had allograft reaction. One case (3.33%) had developed phthisis bulbi. 16 cases (53.33%) had epithelial abnormalities. 7 cases (23.3%) developed postoperative glaucoma. Out of these, 5 cases (71%) had preoperative raised tension. Vascularisation was present in 6 cases (86%) and anterior synechiae were present in 5 cases (71%). ConclusionAge and sex of the patients do not have any effect on the final visual outcome. Patients with regraft are more prone to graft rejection. Presence of preoperative vascularised corneas is more prone to graft rejection. Other preoperative conditions which are associated with increased post keratoplasty complications were presence of anterior synechiae and adherent leucoma