Clinical study of fracture healing in patients with brain nerve injury

Objective: To study the effects of limb fracture combined with cranial nerve injury on bone mineral density, bone microstructure and bone metabolism. Method: 42 patients were randomly divided into simple fracture group and brain injury and fracture group. Serum samples, bone mineral density and levels of serum amino-terminal peptides and osteocalcin were analyzed at 3rd week, 6th week and 3rd month after operation. Results: compared with the fracture group, the volume fraction of the cancellous bone, the thickness of the trabecular bone, the total area of the tibial cortical cross section, serum collagen N telopeptide and osteocalcin level of the brain injury and fracture group were significantly higher in the 3rd and 6th week after operation, and there was no significant difference between the two groups 3 months after the operation. Conclusion: cranial nerve injury can increase local bone mineral density and improve bone microstructure so that to promote bone healing and bone metabolism.