Cornea Hyperosmotic Stress – Induced TRPM 2 Channel Activation Stimulates NLRP 3 Inflammasome Activity in Primary Human Corneal Epithelial Cells

Citation: Zheng Q, Tan Q, Ren Y, et al. Hyperosmotic stress–induced TRPM2 channel activation stimulates NLRP3 inflammasome activity in primary human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2018;59:3259– 3268. https://doi.org/10.1167/ iovs.18-23965 PURPOSE. The purpose of this study was to determine whether either a hyperosmotic or oxidative stress induces NLRP3 inflammasome activation and increases in bioactive IL-1b secretion through transient receptor potential melastatin 2 (TRPM2) activation in primary human corneal epithelial cells (PHCECs).