Hindlimb Skeletal Muscle Function and Femoral Strength in + / G 610 C Osteogenesis Imperfecta Mice ; Impact of Weight-bearing Treadmill Exercise

Osteogenesis imperfecta (OI) is a congenital disorder primarily caused by mutations in COL1A1 and COL1A2 genes. Clinical features vary from mild to lethal and include malformed and easily fractured bone, brittle teeth, curved spines, muscle weakness, loose joints, and blue sclera. Pain is common in OI patients which impedes their lives. Managing OI pain remains suboptimal even with available approaches. Animal models of OI provide an opportunity to better understand the sources of pain in this syndrome and to question the effectiveness of possible treatments.