Targeting sphingosine kinase 1 induces MCL 1 dependent cell death in acute myeloid leukemia Running title : Targeting sphingosine kinase 1 in acute myeloid leukemia

Jason A. Powell, Alexander C. Lewis, Wenying Zhu, John Toubia, Melissa R. Pitman, Craig T. Wallington-Beddoe, Paul A. B. Moretti, Diana Iarossi, Saumya E. Samaraweera, Nik Cummings, Hayley S. Ramshaw Daniel Thomas, Andrew H Wei, Angel F. Lopez, Richard J. D’Andrea, Ian D. Lewis and Stuart M. Pitson 1 Centre for Cancer Biology, University of South Australia and SA Pathology, Frome Road, Adelaide, SA 5000, Australia 2 Schools of Medicine and 5 Biological Sciences, University of Adelaide, Australia 3 Alfred Hospital and Monash University, Department of Haematology, Australian Centre for Blood Diseases, Melbourne, VIC, Australia 4 Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford University, Stanford, CA