The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukaemia blasts . Running title : CNS infiltration in BCP-ALL

1 Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK. 2 Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan. 3 Northern Institute for Cancer Research, Newcastle University, UK. 4 Functional Genomics and Childhood Leukemia Research Center, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel 5 Department of Human Molecular Genetics and Biochemistry, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel 6 Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel. 7 Institute of Cancer and Genomic Sciences, University of Birmingham, UK. 8 Department of Paediatric and Adolescent Haematology and Oncology, Great North Children’s Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. Blood First Edition Paper, prepublished online February 11, 2016; DOI 10.1182/blood-2015-08-665034