Advances in Brief A Distinct Region of Chromosome 19 pl 3 . 3 Associated with the Sporadic Form of Adenoma Malignum of the Uterine Cervix 1

Adenoma malignimi (AM) is known to be one of the malignant tumors that is commonly associated with Peutz-Jeghers syndrome. Recently, the genetic locus of Peutz-Jeghers syndrome was mapped to the telomeric region of chromosome 19p. We analyzed nine sporadic cases of AM with high-density loss of heterozygosity to study the region of chromosome 19p 13.2-13.3 using eight microsatellite markers. Our deletion mapping data revealed a distinct region with 100% loss of heterozygosity frequency at marker O19S2I6. This result indicates that a putative tumor suppressor gene for AM is located at DI9S216 on chromosomal band 19pl3.3 and plays an important role in AM tumorigenesis.