Relevance of a full-length genomic RNA standard and thermal shock step for 1 optimal hepatitis delta virus quantification 2 3 Running title : Thermal shock step for HDV quantification

8 Centro de investigación biomédica en red: enfermedades hepáticas y digestivas 9 (CIBERehd), Instituto de Salud Carlos III, Barcelona, Spain; Liver Pathology Unit, 10 Departments of Biochemistry and Microbiology, Hospital Vall d’Hebron, Universitat 11 Autònoma de Barcelona, Barcelona, Spain; Department of Internal Medicine, 12 University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Liver Unit, 13 Department of Internal Medicine, Hospital Vall d’Hebron, Universitat Autònoma de 14 Barcelona, Barcelona, Spain 15