Trivalent RING Assembly on Retroviral Capsids Activates TRIM 5 Ubiquitination and Innate Immune Signaling Graphical

In Brief TRIM5 self-assembles into a lattice that envelopes retroviral capsids, stimulating virion destruction and innate immune signaling. Fletcher et al. demonstrate that self-assembly induces K63-linked ubiquitination (K63-Ub) of the TRIM5 N terminus that drives innate immune stimulation and degradation. Thus, ordered capsid binding allows TRIM5 to couple virus recognition with antiviral responses.