tions by control of protein – ligand complex conformation : tuning arginine – arene interaction geometry for enhanced electrostatic protein – ligand interactions †

Centre for Analysis and Synthesis, Departm 124, SE-221 00 Lund, Sweden. E-mail: ulf.n Section for Biochemistry and Structural Biol Department of Chemistry, Lund University, SARomics Biostructures AB, Medicon Villag Biophysical Chemistry, Center for Mole Chemistry, Lund University, Box 124, SE-22 Department of Laboratory Medicine, Section 223 62, Lund, Sweden † Electronic supplementary information procedures and physical data for compo statistics for the X-ray crystal structures, 16, 19, and 20 when in complex with alternate positions of 20 compared to galectin-3 in complex and R144 and R18 and copies of H NMR spectra for compo 19–22. See DOI: 10.1039/c7sc04749e Cite this: Chem. Sci., 2018, 9, 1014