Cyclin D 1 rs 9344 G > A polymorphism and gastric cancer risk : a meta-analysis

The association between Cyclin D1 (CCND1) rs9344 G>A (G870A) polymorphism and gastric cancer (GC) has been extensively investigated; however, the results remain conflicting. In the present study, we performed a meta-analysis to further address this issue. We carried out a meta-analysis, recruiting seven publications with 1,350 GC cases and 1,823 controls, to obtain a more comprehensive evaluation between the CCND1 rs9344 G>A polymorphism and the susceptibility of gastric cancer. After combining all eligible studies, we found null association between CCND1 rs9344 G>A polymorphism and GC in all genetic models. In a stratified analysis by ethnicity, significant decreases in GC risk were observed for Caucasians in one genetic model: AA vs. GA+GG (OR, 0.65; 95% CI, 0.44-0.96; P = 0.032). Begg’s Funnel plots and Egger’s tests were created to measure the publication bias, and the shape of funnel was symmetry in four genetic models, suggesting the stability of our findings. The results highlight that CCND1 rs9344 G>A variants may be associated with the risk of gastric cancer among Caucasians.