Synthesis , antibacterial , lipoxygenase and urease inhibitory activities of 2-aminophenol derivatives

In oder to discover potentially active antibacterial compounds, three Schiff bases: 2[(4-methoxybenzylidene)-amino]phenol (5), 2-[(3,4-dimethoxybenzylidene)-amino]phenol (6), 2-[(3,4,5-trimethoxybenzylidene)-amino]phenol (7), were synthesized by the condensation of 2-aminophenol (1) with aldehydes (2-4) in methanol along with H2SO4. The synthesized Schiff bases (5-7) were characterized by H-NMR, IR, EIMS and elemental analysis. The compound with greater –OCH3 groups was found to be more biologically active than others. The antibacterial activity was excellent against S. aureus and B. subtilis, while LOX was excellent for 7 with IC50 19.3 たM.