Figures and Appendix Supplementary Methods : Phosphorylation of FUS low-complexity domain disrupts phase separation , aggregation , and toxicity 1

Department of Pharmacology and Molecular Therapeutics, Uniformed Services University, Bethesda, Maryland 20895, United States Neuroscience Graduate Program,Department of Molecular Pharmacology, Physiology, and Biotechnology, and Graduate Program in Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, United States Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA 18015, USA Johns Hopkins Mass Spectrometry and Proteomic Facility, Johns Hopkins University, Baltimore, Maryland 21218, USA Laboratory of Chemical Physics, National Institutes of Health, Bethesda, MD 20892, USA *Z.M. and V.H.R. contributed equally as “co-first” authors