Revievv Combined Effect of lonizing Ra on Cancer lnduction diation and Alkylating Agents

agents. These agents include genotoxic and non-genotoxic chemical carcinogens such as. tobacco. hormones. viruses. metals etc, Carcinogenesis is a multi-step process that accumulates several genetic and epigenetic changes of oncogenes and tumor suppressor genes, For agents having similar bio]ogical function and affecting the same step of carcinogenesis. additivity is generally expected. while for agents acting at different rate-limiting step.