Pab1-based synthetic proteins and yeast robustness

We have previously identified the poly(A) binding protein Pab1 as a promising target to improve stress tolerance. Pab1 is a component of stress granules and a master regulator of mRNA metabolism. It is composed of four RNA Recognition Motifs (RRM), a flexible linker rich of proline (for this reason named P domain) and a carboxy-terminal domain (C domain); this modularity is responsible of the binding to mRNA poly(A) tails and of the simultaneous interaction with diverse proteins involved in mRNA biogenesis and decay.