Drug-induced liver injury (DILI) Amoxicillin-clavulanic acid HLA-DRB1*15:02 Major Histocompatibility Complex (MHC) Peptide-binding groove diagnostic genotyping Word count: 3458 Figures: 2 Tables: 2 Key Points: 1) Candidate gene and genome-wide association studies (GWAS) in well characterized cases h

1 Department of Gastroenterology and Hepatology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433 2 NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK. 3 Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK. 4 The Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK 5 Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK