THROMBOSIS AND HEMOSTASIS Computationally designed liver-speci fi c transcriptional modules and hyperactive factor IX improve hepatic gene therapy

Department of Gene Therapy and Regenerative Medicine, Free University of Brussels, Brussels, Belgium; Center for Molecular and Vascular Biology, Department of Cardiovascular Medicine, University of Leuven, Leuven, Belgium; Department of Pediatrics, Division of Metabolism, University of Zurich, Zurich, Switzerland; and Inflammation Research Center, Vlaams Instituut voor Biotechnologie, and Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium