An evaluation of the use of adrenomedullin on cisplatin ototoxicity in rats Ratlarda cisplatin ototoksisitesinde adrenomedüllinin kullaniminin etkinliği

Purpose: The aim of this study was to evaluate the efficacy of adrenomedullin on damage associated with cisplatin ototoxicity created in an experiment model. Material and Methods: A total of 32 Wistar Albino rats were separated into 4 groups of 8. To the rats in Group 1 (control), 1% acetic acid was administered intraperitoneally and intratympanically, to Group 2, cisplatin (10mg/kg/2 days) + intratympanic acetic acid, to Group 3, cisplatin + intraperitoneal adrenomedullin (12 μg/kg) and to Group 4, cisplatin +0.10.3ml intratympanic adrenomedullin (12 μg/kg). The rats were sacrificed and serum and ear tissue samples were taken for histopathological examination and examination of oxidative stress levels. The drugs were administered on the first 5 days and signal (SNR) measurements of the auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE) were made on days 0, 5 and 15. The rats were sacrificed and serum and ear tissue samples were taken for histopathological examination and examination of oxidative stress levels. Results: A statistically significant difference was determined in the cisplatin +int adrenomedullin group in the Auditory brain response (ABR) measurements on days 0, 5 and 15 (p=0.001). In the Distortion product emission (DPOAE) measurements, the between differences at 16000 frequency intraperitoneal adrenomedullin group were accepted as statistically significant (p=0.003). The histopathological Cukurova Med J 201 DOI: 10.17826/cumj. Nagihan Bilal, Kahramanmaras Sutcu Imam University, Faculty of E-mail: nagihanyazan@gmail.com 29.11.2018 Çevrimiçi yayın / Published online: ş2 , Abdulkadir Yasir Bahar3 1 , Adem Doğaner5 , Meltem Güngör6 , Faculty of Medicine, Department of Otorhinolaryngology, 4Department of Anesthesia and reanimation, Cukurova Medical Journal 2019;44(2):1.